Human T-Lymphotrophic Virus Type-I: A Unique Association with Myelopathy in Sjogren's Syndrome

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Human T-Lymphotrophic Virus Type-I: A Unique Association with Myelopathy in Sjögren’s Syndrome

Microbes play the most intricate and crucial role in the education of the immune system. Exposure to pathogens elicits specific immune response to clear the infection. After elimination of infectious pathogens, the immune cells undergo apoptosis during the contraction phase, and the remaining cells return to the quiescent memory phase [1]. During the primary and secondary responses, some of the...

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Association of IL-10 Gene Polymorphisms and Human T Lymphotropic Virus Type I-Associated Myelopathy/tropical Spastic Paraparesis in North-East of Iran (Mashhad)

  The underlying mechanisms leading to the development of human T-cell lymphotropic virus type I (HTLV-I) associated myelopathy/tropical spastic paraparesis (HAM/TSP) in HTLV-I infected individuals are not fully understood. Host genetic factors appear to be involved as risk factors for developing HAM/TSP. We investigated the possible contribution of interleukin-10 (IL-10) as a risk factor to HA...

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[Human T-Lymphotropic Virus Type I-Associated Myelopathy].

Human T-lymphotropic virus type I (HTLV-I)-associated myelopathy (HAM) is a chronic progressive myelopathy that is characterized by spastic paraparesis with bladder dysfunction that is derived from bilateral pyramidal tract involvement and neurogenic bladder, respectively. The primary neuropathological feature of HAM is chronic inflammation in the spinal cord, mainly the lower thoracic cord, wh...

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ژورنال

عنوان ژورنال: Clinical Microbiology: Open Access

سال: 2015

ISSN: 2327-5073

DOI: 10.4172/2327-5073.1000e123